منابع مشابه
Renal subcapsular islet cell transplantation.
Islet cell transplantation has been associated with ultimate graft rejection. This preliminary study investigates the use of the renal subcapsular region as a site for placement of canine islet cell allografts. A new noncollagenase mechanical technique was used for preparation of the allografts. Animals in group I (N = 6) died of hyperglycemia in 4.0 +/- 1.89 days (X +/- SD) after pancreatectom...
متن کاملPancreas and islet cell transplantation.
Currently, for the patient with type 1 diabetes, a definitive treatment without resorting to the use of exogenous insulin can be achieved only with pancreas or islet cell transplantation. These means of restoring beta-cell mass can completely maintain essentially normal long-term glucose homeostasis, although the need for powerful immunosuppressive regimens limits their application to only a su...
متن کاملClinical islet cell transplantation – recent advances
Type-1 diabetes mellitus (T1DM) caused by autoimmune destruction of insulin-producing beta-cells essentially requires treatment with exogenous insulin therapy. Despite the education, technology and improvements in insulin formulations, patients face the ongoing life-threatening hypoglycaemia with poor quality of life as well as progressive disease leading to microand macro-vascular complication...
متن کاملIslet Cell Biology, Regeneration, and Transplantation
1 Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA 2Alpha Hospital and Research Center, Institute of Diabetes and Endocrinology, Madurai, Tamilnadu 625009, India 3Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA 4Baylor Simmons Transplant Institute, ...
متن کاملLaparoscopic approach for islet cell transplantation.
SubtotaJ pancreatectomy with preservation of the duodenum was performed in two mongrel dogs weighing 12 and 13.5 kg. The islets were separated by collagenase digestion (Boehringer-Mannheim P, Mannheim. Germany 1.5 mg/mL) using the automated method and purified on Eurocollins-Ficoll discontinuous gradients.2 The final preparation comprised approximately 291,000 and 146,000 islets with an average...
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ژورنال
عنوان ژورنال: Pharmacological Research
سال: 2015
ISSN: 1043-6618
DOI: 10.1016/j.phrs.2015.02.010